This combination is used to treat or prevent certain types of vascular including and . pain can sometimes be caused by widened vessels in the head. works by narrowing these widened vessels. increases the absorption of ergotamine and also narrows widened blood vessels. Migraine headaches usually last for hours or longer. Treatment consists of removal of the offending drug by induction of emesis, gastric lavage, and catharsis. Maintenance of adequate pulmonary ventilation, correction of hypotension and control of convulsions and blood pressure are important considerations. Treatment of peripheral vasospasm should consist of warmth, but not heat, and protection of the ischemic limbs. Vasodilators may be beneficial but caution must be exercised to avoid aggravating an already existent hypotension.
Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior addiction. This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction. Most cluster headache sufferers respond to drug treatments designed to prevent attacks or minimize their intensity. Redfield MM, Nicholson WJ, Edwards WD, Tajik AJ "Valve disease associated with ergot alkaloid use: echocardiographic and pathologic correlations.
Allergic: Localized edema and itching. Insert 1 suppository at the first sign of migraine headache symptoms, or after an attack has already begun. This medication must not be used during pregnancy. It may harm an unborn baby. Discuss the use of reliable forms of birth control such as condoms, birth control pills with your doctor. If you become pregnant or think you may be pregnant, tell your doctor right away.
What are the common side effects of FROVA? Heart attack and other heart problems. Heart problems may lead to death. RELPAX is not intended for the prevention of migraine attacks. Rare cases of a solitary rectal or anal ulcer have occurred from abuse of ergotamine suppositories usually in higher than recommended doses or with continual use at the recommended dose for many years. Spontaneous healing occurs within usually 4-8 weeks after drug withdrawal.
Drowsiness is the most prominent CNS effect of this drug. Procedure: For the best results, dosage should start at the first sign of an attack. Adults: Take 2 tablets at the start of attack; 1 additional tablet every ½ hour, if needed for full relief maximum 6 tablets per attack, 10 per week. Please read this information before you start taking RELPAX and each time you get a refill. RELPAX is for people who have been diagnosed with migraine headaches. Ibraheem JJ, Paalzow L, Tfelt-Hansen P "Linear pharmacokinetics of intravenous ergotamine tartrate. SCAG Sandoz Clinical Assessment-Geriatric. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. 'Multum' is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. That can make the headache worse and continue indefinitely. Patients should be advised that two tablets of ergotamine tartrate and caffeine tablets should be taken at the first sign of a migraine headache. No more than 6 tablets should be taken for any single migraine attack. No more than 10 tablets should be taken during any 7-day period. Administration of ergotamine tartrate and caffeine tablets should not exceed the dosing guidelines and should not be used for chronic daily administration see . Ergotamine tartrate and caffeine tablets should be used only for migraine headaches. It is not effective for other types of headaches and it lacks analgesic properties. Patients should be advised to report to the physician immediately any of the following: numbness or tingling in the fingers and toes, muscle pain in the arms and legs, weakness in the legs, pain in the chest or temporary speeding or slowing of the heart rate, swelling or itching.
Use only if a clear diagnosis of migraine has been established. Safety and effectiveness in pediatric patients have not been established. Dispense in well-closed container. Total weekly dosage should not exceed 10 tablets. Convulsions may rarely occur. USP. Caffeine is known to cross the placenta and has been shown to be teratogenic in animals. Ergotamine crosses the placenta in small amounts, although it does not appear to be embryotoxic in this quantity.
The procedure involves positioning a fine electrode under the at the base of the skull. This is attached to a wire leading to a -like device implanted elsewhere in the body. An external generator controls the degree of stimulation the patients receive. This Patient Information summarizes the most important information about RELPAX. Never use more than your prescribed dose of caffeine and ergotamine. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. An overdose of caffeine and ergotamine can be fatal. Ask your pharmacist about the safe use of those products. SUPPOSITORY 78-33 NOVARTIS” printed in fuchsia. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Using certain medications together with caffeine and ergotamine can cause even greater decreases in blood flow than caffeine and ergotamine used alone. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects.
RELPAX is not used to prevent or decrease the number of migraine headaches you have. Eletriptan is excreted in human milk. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Talk to your doctor about the best way to feed your baby if you take RELPAX. Do not use more than 2 suppositories for a single migraine headache or more than 5 suppositories during any 7-day period without first checking with your doctor. Do not take a rectal suppository by mouth. It is for use only in your rectum. RELPAX as compared to placebo. Merello MJ, Nogues MA, Leiguarda RC, Lopez Saubidet C "Dystonia and reflex sympathetic dystrophy induced by ergotamine. The extremities are most frequently affected by arterial spasm and amputation has occasionally been required. Clementz GL, Dailey JW "Psychotropic effects of caffeine. Grapefruit and grapefruit juice may interact with ergotamine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. This medication can harm an unborn baby or a nursing baby. Do not use caffeine and ergotamine if you are pregnant or breast-feeding. Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. Seek emergency medical attention if you think you have used too much of this medicine. An overdose of caffeine and ergotamine can be fatal. What should I avoid while using caffeine and ergotamine?
Coadministration of ergotamine with potent CYP 3A4 inhibitors such as protease inhibitors or macrolide antibiotics has been associated with serious adverse events; for this reason, these drugs should not be given concomitantly with ergotamine See . While these reactions have not been reported with less potent CYP 3A4 inhibitors, there is a potential risk for serious toxicity including vasospasm when these drugs are used with ergotamine. Examples of less potent CYP 3A4 inhibitors include: saquinavir, nefazodone, fluconazole, fluoxetine, grapefruit juice, fluvoxamine, zileuton, metronidazole, and clotrimazole. These lists are not exhaustive, and the prescriber should consider the effects on CYP 3A4 of other agents being considered for concomitant use with ergotamine. Contact your doctor or health care provider right away if any of these apply to you. Do not stop taking any medications without consulting your healthcare provider. Caucasians and non-Caucasian patients. Ergot drugs are known to inhibit prolactin but there are no reports of decreased lactation with ergotamine tartrate and caffeine. Ergotamine is excreted in breast milk and may cause symptoms of vomiting, diarrhea, weak pulse and unstable blood pressure in nursing infants. Because of the potential for serious adverse reactions in nursing infants from ergotamine tartrate and caffeine tablets, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. If the initial dose does not relieve your headache, an additional dose may be needed according to your doctor's instructions. Do not use a dose of Cafergot suppositories within 1 hour of your last dose. Coadministration of ergotamine with potent CYP 3A4 inhibitors ritonavir, nelfinavir, indinavir, erythromycin, clarithromycin, and troleandomycin has been associated with acute ergot toxicity ergotism characterized by vasospasm and ischemia of the extremities see PRECAUTIONS: Drug Interactions with some cases resulting in amputation. Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Below 77ºF 25ºC; tight container sealed foil. Protect from moisture. Do not take Cafergot for any other kind of headaches. Cafergot is not effective in treating other types of headaches.
If you have any questions about Cafergot, please talk with your doctor, pharmacist, or other health care provider. Caffeine and ergotamine may also be used for purposes not listed in this medication guide. Dahlof C "Placebo-controlled clinical trials with ergotamine in the acute treatment of migraine. P450 3A metabolism of ergotamine see CONTRAINDICATIONS. Ergotamine has also been shown to be an inhibitor of cytochrome P450 3A catalyzed reactions. No pharmacokinetic interactions involving other cytochrome P450 isoenzymes are known. Cafergot is generally taken at the first sign of a migraine attack. Another 2 mg tablet may be taken at 30 minute intervals if necessary, but dosage must not exceed three tablets in any 24-hour period. Total weekly dosage should not exceed five tablets 10 mg. Ergotamine sublingual tablets should not be used for chronic daily administration. What other drugs will affect ergotamine? Dosage is based on your medical condition and response to therapy. This works best if it is used as the first signs of the occur. If you wait until the has worsened, the medication may not work as well.
RELPAX. Such reactions can be life threatening or fatal. This medication usually should be used only as needed. It is not meant for long-term daily use. The maximum dose is 2 for a single attack and 5 suppositories in any 7-day period. Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior . This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction. FDA pregnancy category X. This medication can harm an unborn baby or cause birth defects. Do not use caffeine and ergotamine if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medication. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. If you miss a dose of Cafergot and you still have a headache, take it as soon as you remember. Do not take a dose of Cafergot within 30 minutes of your last dose. Do not take 2 doses at once. Caffeine and ergotamine may also be used for purposes not listed in this medication guide. What is the most important information I should know about caffeine and ergotamine? Cafergot is contraindicated in pregnancy due to the oxytocic effects of ergotamine. See CONTRAINDICATIONS. It is not known if RELPAX is safe and effective in children. C; tight, amber glass bottle. The mean absolute bioavailability of eletriptan is approximately 50%.
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The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. If any of these effects persist or worsen, tell your doctor or promptly. All medicines may cause side effects, but many people have no, or minor, side effects. CYP450 3A4. Because pharmacokinetic interactions involving grapefruit juice are often subject to a high degree of interpatient variability, the extent to which a given patient may be affected is difficult to predict.
Overuse of drugs to treat sudden attacks can sometimes lead to worsening of headache medication overuse headache or rebound headache. Therefore, do not use this medication more often or for longer than prescribed. AUC 34% and half-life. The Cmax was increased by 18%. Do not take more than 6 caffeine and ergotamine tablets per day or more than 10 tablets per week. Cafergot is a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches. Dispense in a tight, light-resistant container.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. FROVA is a prescription medicine used to treat migraine attacks in adults.
Manufactured By: Geneva Pharmaceuticals, Inc. Hypersensitivity to any of the components. Migergot, Migranal, or Methergine. Do not share this medication with another person, even if they have the same symptoms you have. Tell your doctor about your symptoms.